Age’s Window

Metabolism of AGEs – Bacterial AGEs Are Degraded by Metallo-Proteases

Advanced Glycation End Products (AGEs) are the final products of non-enzymatic protein glycation that results in loss of protein structure and function. We have previously shown that in E. coli AGEs are continually formed as high-molecular weight protein complexes. Moreover, we showed that AGEs are removed from the cells by an active, ATP-dependent secretion and that these secreted molecules ha...

Quality through the ages.

The Ages of Life

already existing high circulatory levels of cortisol and the Circadian rhythm of cortisol production. The final paper presents a useful plot of cortisol against ACTH in plasma in the normal state and in syndromes involving pituitary-adrenal pathology. Good bibliographies accompany the papers and the editors have provided a glossary of abbreviations and formulas for pharmaceutical brand names oc...

Craniotomy through the ages.

Today, the Specialist in Otorhinolaryngology often has to perform surgery requiring an endocranial approach, as, for instance, in the case of neoplastic or inflammatory disorders, or even in malformations. These specialists should, therefore, not forget one of the most important Chapters in the History of Medicine and Ethnology: that related to the evolution of craniotomy over thousands of year...

Stellar ages from asteroseismology

Asteroseismology has been recognized for a long time as a very powerful mean to probe stellar interiors. The oscillations frequencies are closely related to stellar internal structure properties via the density and the sound speed profiles. Since these properties are in turn tightly linked with the mass and evolutionary state, we can expect to determine the age and mass of a star from the compa...